Mitosis puts sisters in a strained relationship: Force generation at the kinetochore
نویسندگان
چکیده
منابع مشابه
Mitosis: Disorderly Conduct at the Kinetochore
Conventional models posit that microtubules bound to kinetochores act coordinately during chromosome movement. Such models need to be revised in the light of new data demonstrating uncoordinated behavior among kinetochore-associated microtubules.
متن کاملA Mathematical Model for Force Generation at the Kinetochore-Microtubule Interface
In this paper we construct and analyze a mathematical model for kinetochore (Kt) motors operating at the chromosome/microtubule interface. Motor dynamics are modeled using a jump-diffusion process that incorporates biased diffusion due to the binding of microtubules (MTs) by Kt binder elements and thermal ratchet forces that arise when the polymer grows against the Kt plate. The resulting force...
متن کاملPoleward force at the kinetochore in metaphase depends on the number of kinetochore microtubules
To examine the dependence of poleward force at a kinetochore on the number of kinetochore microtubules (kMTs), we altered the normal balance in the number of microtubules at opposing homologous kinetochores in meiosis I grasshopper spermatocytes at metaphase with a focused laser microbeam. Observations were made with light and electron microscopy. Irradiations that partially damaged one homolog...
متن کاملKinetochore Orientation in Mitosis and Meiosis
Kinetochores are the major point of contact between spindle microtubules and chromosomes. They are assemblies of more than 50 different proteins and take part in regulating and controlling their own interaction with the spindle. We review recent advance in understanding how kinetochores are properly placed onto the chromosome, and how their interaction with the microtubules of the spindle is re...
متن کاملTraction force on a kinetochore at metaphase acts as a linear function of kinetochore fiber length
We are investigating the relation between the force pulling a kinetochore poleward and the length of the corresponding kinetochore fiber. It was recognized by Ostergren in 1950 (Hereditas 36:1-19) that the metaphase position of a chromosome could be achieved by a balance of traction forces were proportional to the distance from kinetochore to pole. For the typical chromosome (i.e., a meiotic bi...
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ژورنال
عنوان ژورنال: Experimental Cell Research
سال: 2012
ISSN: 0014-4827
DOI: 10.1016/j.yexcr.2012.04.008